Comments on Information on Genes: How quickly does inbreeding produce homozygosity?...

Thanks CGJ. Your profile is currently not availab...

2009-02-05T00:01:00.000-05:00

Thanks CGJ.
Your profile is currently not available. We do ask that those who comment identify themselves. "We are looking for answers from people with some expertise, and you will be asked to log in so that we know who you are."

The paper you cite, Hildebrandt et al. , is more about localized homozygosity around disease loci, whereas the question was more about residual heterozygosity after systematic inbreeding.

Please see A Systematic Approach to Mapping Reces...

2009-01-30T06:29:00.000-05:00

Please see A Systematic Approach to Mapping Recessive Disease Genes in Individuals from Outbred Populations

http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000353

Greetings! Some recent work I've done on this iss...

2008-01-09T18:05:00.000-05:00

Greetings!

Some recent work I've done on this issue in nematodes (soon to be submitted?) has led me to a couple of special cases that may be of interest: all full-sib inbreeding and all half-sib inbreeding. An authority on this is Dr. Thomas Nagylaki, of the Univ. of Chicago. In Chapter 9 of his 1992 book, Introduction to Theoretical Population Genetics (Springer-Verlag, Biomathematics series), Nagylaki derives precise expressions for these two cases.

If all individuals in every generation were full-sibs, the extent of expected heterozygosity (ht) is given by ht ≈ 1.17h0 (0.809)t, when t»1, where h0 is the initial extent of heterozygosity and t is the number of generations of inbreeding. If the offspring in every generation were exclusively half-sibs, then ht ≈ 1.106h0 (0.890)t.

So, after 20 generations of inbreeding, ht is approximately 1.7 % of h0 in the full-sib case and 10.8 % in the half-sib case.